2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine → 2-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

HRID 887456ノート

反応式

HRID 887456 の反応式
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[C:12]([F:13])=[N:11][CH:10]=[CH:9][N:8]=2)[CH2:3][CH2:2]1>CCOC(C)=O.[OH-].[OH-].[Pd+2]>[F:13][C:12]1[C:7]([CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:8][CH:9]=[CH:10][N:11]=1

参加物

4

反応物 1

HCID 593511782-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine

生成物 1

HCID 593512282-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a round bottomed flask was added 2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine (1.1754 g, 6.52 mmol) and palladium hydroxide on carbon (0.458 g, 0.652 mmol) in EtOAc (21.75 mL). The round bottomed flask was flushed with argon and then placed under vacuum three times. A hydrogen balloon was then attached to the reaction. After stirring overnight, the reaction was filtered through celite to provide 2-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine. [M+H]=183.1.

後処理

  1. customThe round bottomed flask was flushed with argon
  2. customA hydrogen balloon was then attached to the reaction
  3. filtrationthe reaction was filtered through celite

出典と根拠

ORDレコード
ord-48db84fece684ccbb05fcbab8cfa944a
出典データセット
uspto-grants-2012_08
特許番号
US08247418B2

反応ノート

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