1-Methylpiperazine → HCID 21959580、化合物

反応式

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[Br:14])([CH3:4])([CH3:3])[CH3:2].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[Br:14][C:6]1[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][C:9]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[C:8]([N+:11]([O-:13])=[O:12])[CH:7]=1

参加物

反応物 2

HCID 531671-Methylpiperazine

HCID 2385872-Bromo-1-tert-butyl-4-nitrobenzene

生成物 1

HCID 21959580HCID 21959580、化合物

反応条件

温度: 130 °C

実験手順

A mixture of 1-(tert-butyl)-2-bromo-4-nitrobenzene (3 g) and N-methylpiperazine (8 g) was heated neat at 130° C. for 4 h. The residue was purified by column chromatography to give 1-[4-bromo-5-(tert-butyl)-2-nitrophenyl]-4-methylpiperazine, which was hydrogenated to furnish 4-(tert-butyl)-2-(4-methylpiperazinyl)-phenylamine.

後処理

customThe residue was purified by column chromatography

出典と根拠

ORDレコード: ord-c9dc60bf835a49b1b7a72af195e4b200
出典データセット: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08247430B2

反応ノート

読み込み中…

参加物