2-Cyano-5-fluoropyridine → (5-Fluoropyridin-2-yl)methanamine
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1>CO.Cl.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][NH2:9])=[N:6][CH:7]=1参加物
5
実験手順
The mixture of 5-fluoro-pyridine-2-carbonitrile (0.16 g, 1.27 mmol) and Pd/C (0.030 g, 10% wt) in 15 ml of MeOH and 0.50 ml of concentrated HCl was placed under H2 which was provided by a balloon and stirred at RT for 4 h, filtered through Celite®, condensed, the residue was purified by flash column chromatography. The titled compound was obtained as a light yellowish solid. MS (ES+): 127.2 (free base)(M+H)+. Calc'd for C6H7FN2 (free base)—126.13.
後処理
- customwas provided by a balloon
- filtrationfiltered through Celite®, condensed
- customthe residue was purified by flash column chromatography
出典と根拠
- ORDレコード
- ord-0228a8820a5a43a1aaab5bb08b76cb27
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247430B2
反応ノート
読み込み中…