Trifluoroacetic acid → 3-Nitro-5,6,7,8-tetrahydro-1,6-naphthyridine
反応式
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[N:14]=[CH:13][C:12]([N+:18]([O-:20])=[O:19])=[CH:11][C:10]=2[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N+:18]([C:12]1[CH:13]=[N:14][C:15]2[CH2:16][CH2:17][NH:8][CH2:9][C:10]=2[CH:11]=1)([O-:20])=[O:19]参加物
4
実験手順
To the solution of 3-nitro-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester (6.14 g, 22 mmol) in CH2Cl2 (60 mL) was added TFA (7 mL). The reaction was stirred for 18 h at RT. After evaporation of the solvent, the residue was taken into water and neutralized with saturated NaHCO3 aqueous solution. The solid was filtered and washed with cold water and dried. The solid was recrystallized from CH3CN to give desired title compound as pale white solid. MS (ES+): 180.1 (M+H)+. Calc'd for C8H9N3O2—179.07.
後処理
- customAfter evaporation of the solvent
- filtrationThe solid was filtered
- washwashed with cold water
- customdried
- customThe solid was recrystallized from CH3CN
出典と根拠
- ORDレコード
- ord-3061eb9e83f74aa99a9698f324ea0669
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247430B2
反応ノート
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