Oxalyl chloride → 2-Chloro-4,5-difluorobenzoyl Isocyanate

HRID 887891ノート

反応式

HRID 887891 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:14](Cl)=[O:15]>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:6]=[C:14]=[O:15])=[O:5]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 23171512-Chloro-4,5-difluorobenzamide

生成物 1

HCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Chloro-4,5-difluorobenzamide was dissolved in dichloromethane, mixed with 1.5 eq. of oxalyl chloride and heated to reflux for 16 hours. The reaction mixture was concentrated under high vacuum and employed in stage b without further purification.

後処理

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe reaction mixture was concentrated under high vacuum
  4. customemployed in stage b without further purification

出典と根拠

ORDレコード
ord-9117c9352e584eaf92331cbf464dca96
出典データセット
uspto-grants-2012_08
特許番号
US08247452B2

反応ノート

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