Methyl Isocyanate → Glycogen Phosphorylase Inhibitor

HRID 887894ノート

反応式

HRID 887894 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:23][CH3:24])=[C:6]([NH:8][C:9]([NH:11][C:12](=[O:22])[C:13]2[CH:18]=[C:17]([F:19])[C:16]([F:20])=[CH:15][C:14]=2[Cl:21])=[O:10])[CH:7]=1.[CH3:25][N:26]=[C:27]=[O:28]>C(#N)C>[Cl:21][C:14]1[CH:15]=[C:16]([F:20])[C:17]([F:19])=[CH:18][C:13]=1[C:12]([NH:11][C:9](=[O:10])[NH:8][C:6]1[CH:7]=[C:2]([NH:1][C:27]([NH:26][CH3:25])=[O:28])[CH:3]=[CH:4][C:5]=1[O:23][CH3:24])=[O:22]

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 115665791-(2-Chloro-4,5-difluorobenzoyl)-3-(5-amino-2-methoxyphenyl)urea

生成物 1

HCID 10070301Glycogen Phosphorylase Inhibitor収率 91%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

600 mg (1.7 mmol) of 1-(5-amino-2-methoxyphenyl)-3-(2-chloro-4,5-difluoro-benzoyl)urea were dissolved in 5 ml of acetonitrile, and 69 mg (1.7 mmol) of methyl isocyanate were added. After stirring at room temperature for one hour, the resulting precipitate was filtered off with suction. 638 mg (91%) of the desired product were obtained.

後処理

  1. filtrationthe resulting precipitate was filtered off with suction

出典と根拠

ORDレコード
ord-f817b42c8b09429f9edb9a88ec90dfc4
出典データセット
uspto-grants-2012_08
特許番号
US08247452B2

反応ノート

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