5,5-dimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepine → 5,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamine
反応式
[CH3:1][C:2]1([CH3:16])[CH2:8][CH2:7][CH2:6][NH:5][C:4]2[CH:9]=[C:10]([N+:13]([O-])=O)[CH:11]=[CH:12][C:3]1=2>CO.[Pd]>[CH3:1][C:2]1([CH3:16])[CH2:8][CH2:7][CH2:6][NH:5][C:4]2[CH:9]=[C:10]([NH2:13])[CH:11]=[CH:12][C:3]1=2参加物
4
実験手順
5,5-Dimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepine (350 mg, 1.6 mmol) was dissolved in MeOH. The atmosphere was replaced by Argon and a catalytic amount of Pd/C was added. The atmosphere was replaced by H2 and the reaction was stirred for 72 h at RT. The Pd/C was filtered and the MeOH was removed to give 5,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamine.
後処理
- filtrationThe Pd/C was filtered
- customthe MeOH was removed
出典と根拠
- ORDレコード
- ord-cd4f9b87df7445a38c659676f1f7613e
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247556B2
反応ノート
読み込み中…