Acetic Acid → 2-oxo-1H,2H,3H-pyrrolo[2,3-b]pyridine-4-carbonitrile

HRID 888125ノート

反応式

HRID 888125 の反応式
Br[C:2]1(Br)[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[N:6][C:5]=2[NH:4][C:3]1=[O:13].CC(O)=O>CC#N.[Zn]>[O:13]=[C:3]1[NH:4][C:5]2[N:6]=[CH:7][CH:8]=[C:9]([C:11]#[N:12])[C:10]=2[CH2:2]1

参加物

5

反応物 2

HCID 176Acetic AcidHCID 69264126HCID 69264126、化合物

生成物 1

HCID 692637962-oxo-1H,2H,3H-pyrrolo[2,3-b]pyridine-4-carbonitrile

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 6342Acetonitrile溶媒

実験手順

To a stirred solution of 3,3-dibromo-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (4 g) in CH3CN (75 mL) was added AcOH (2 mL) followed by Zinc dust (4, 63 mmol). Mixture was stirred for 2 h at RT and was filtered. Solvent was evaporated and MeOH was added. A solid precipitated, which was filtered and dried.

後処理

  1. filtrationwas filtered
  2. customSolvent was evaporated
  3. additionMeOH was added
  4. customA solid precipitated
  5. filtrationwhich was filtered
  6. customdried

出典と根拠

ORDレコード
ord-827029395fb14d1cb8aec7a5b996de41
出典データセット
uspto-grants-2012_08
特許番号
US08247556B2

反応ノート

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