Hydrochloric Acid → 7H-pyrrolo[2,3-d]pyrimidin-4-ylmethanamine dihydrochloride
反応式
[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[C:4]([C:10]#[N:11])=[N:3][CH:2]=1.[ClH:12]>CCO.[Pd]>[ClH:12].[ClH:12].[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[C:4]([CH2:10][NH2:11])=[N:3][CH:2]=1参加物
5
実験手順
7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile (86 mg, 0.597 mmol) was dissolved in EtOH (2 mL), then added concentrated HCl (0.2 mL, 2.39 mmol) and 10% Pd/C (20 mg). The reaction was put under a balloon of H2 gas and stirred for 6 h. The mixture was filtered through a pad of Celite®, washing with MeOH. The filtrate was concentrated in vacuo to yield C-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-methylamine dihydrochloride as an orange solid.
後処理
- filtrationThe mixture was filtered through a pad of Celite®
- washwashing with MeOH
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-dfaf944ec0fc4ea19cada13d08d0b2c9
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247556B2
反応ノート
読み込み中…