Diisopropylethylamine → HCID 58941998、化合物

HRID 888161ノート

反応式

HRID 888161 の反応式
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][NH:11][C:12]2[N:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14]([OH:16])=O)=[CH:2]1.[NH2:21][C:22]1[CH:31]=[C:30]2[C:25]([C:26]([CH3:34])([CH3:33])[CH2:27][C:28](=[O:32])[NH:29]2)=[CH:24][CH:23]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>O.CN(C=O)C>[CH3:33][C:26]1([CH3:34])[C:25]2[C:30](=[CH:31][C:22]([NH:21][C:14]([C:13]3[C:12]([NH:11][CH2:10][C:3]4[C:4]5[C:5](=[N:6][CH:7]=[CH:8][CH:9]=5)[NH:1][CH:2]=4)=[N:20][CH:19]=[CH:18][CH:17]=3)=[O:16])=[CH:23][CH:24]=2)[NH:29][C:28](=[O:32])[CH2:27]1

参加物

7

反応物 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 144764787-Amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-oneHCID 692655932-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylamino)nicotinic acid

生成物 1

HCID 58941998HCID 58941998、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

2-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methylamino)nicotinic acid (100 mg, 0.37 mmol), 7-amino-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one (65 mg, 0.37 mmol), TBTU (133 mg, 0.41 mmol) and DIEA (0.07 mL, 0.41 mmol) was added to DMF (1 mL). The reaction was run at RT for 24 h. The reaction was then diluted with water and the resultant precipitate was filtered and purified using flash column to afford product. MS (ES+): 441.5 (M+H). Calc'd. for C25H24N6O2—440.20.

後処理

  1. filtrationthe resultant precipitate was filtered
  2. custompurified
  3. customto afford product

出典と根拠

ORDレコード
ord-3cd1cb525e31407dbf28509ee92f3a0a
出典データセット
uspto-grants-2012_08
特許番号
US08247556B2

反応ノート

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