2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 2-Chloro-4-[1-(2,2-difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

HRID 8882

反応式

HRID 8882 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[CH:4][N:3]=1.[F:14][CH:15]([F:24])[CH2:16][N:17]1[CH:21]=[C:20](I)[N:19]=[C:18]1[CH3:23]>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:20]2[N:19]=[C:18]([CH3:23])[N:17]([CH2:16][CH:15]([F:24])[F:14])[CH:21]=2)[CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 219853912-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridineHCID 219853931H-Imidazole, 1-(2,2-difluoroethyl)-4-iodo-2-methyl-

生成物 1

HCID 112890312-Chloro-4-[1-(2,2-difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

実験手順

The title compound, MS: m/e=282.0 (M+H+), was prepared in accordance with the general method of example A, step 2, from 2-chloro-4-trimethylsilanylethynyl-pyridine and 1-(2,2-difluoro-ethyl)-4-iodo-2-methyl-1H-imidazole.

出典と根拠

ORDレコード
ord-f3776236429f4aeb87a7c0b85091fbfc
出典データセット
uspto-grants-2006_08
特許番号
US07091222B2

関連ノート

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