Trifluoroacetic acid → Trifluoroacetic acid

HRID 888380ノート

反応式

HRID 888380 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([C:21]([O:23][CH3:24])=[O:22])[CH:11]=[C:12]([CH:20]=2)[C:13]([O:15]C(C)(C)C)=[O:14])=[N:6][CH:7]=1.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>ClCCl>[C:27]([OH:29])([C:26]([F:31])([F:30])[F:25])=[O:28].[CH3:24][O:23][C:21]([C:10]1[CH:11]=[C:12]([CH:20]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=2)[CH:9]=1)[C:13]([OH:15])=[O:14])=[O:22]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 68499855tert-Butyl methyl 5-(5-methylpyridin-2-yl)isophthalate

生成物 2

HCID 6422Trifluoroacetic acidHCID 684994173-(Methoxycarbonyl)-5-(5-methylpyridin-2-yl)benzoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl methyl 5-(5-methylpyridin-2-yl)isophthalate in dichloromethane (75 mL) was added 25 mL of trifluoroacetic acid. After 16 h, the reaction was concentrated and dried under vacuum to give TFA salt of the title compound (6.5 g). MS 272.1 (M+1).

後処理

  1. concentrationthe reaction was concentrated
  2. customdried under vacuum

出典と根拠

ORDレコード
ord-ea1ada1909f640bc8d7b2de2c47a53ca
出典データセット
uspto-grants-2012_08
特許番号
US08247401B2

反応ノート

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