Sodium borohydride → [3-Chloro-5-(2-hydroxymethyl-4-nitro-phenoxy)-phenyl]-acetic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:13]=2[CH:21]=[O:22])[CH:8]=[C:7]([Cl:23])[CH:6]=1.[BH4-].[Na+]>CO>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:13]=2[CH2:21][OH:22])[CH:8]=[C:7]([Cl:23])[CH:6]=1参加物
4
実験手順
To [3-chloro-5-(2-formyl-4-nitro-phenoxy)-phenyl]acetic acid methyl ester (3.7 g, 10.6 mmol) in MeOH (30 mL) was added sodium borohydride (0.52 g, 13.8 mmol), and the reaction was stirred at room temperature for 20 minutes. After work-up with EtOAc and H2O, the crude material was purified by silica gel chromatography to give the title compound.