Nitric Acid → 6-Bromo-3,4-difluoro-2-nitrophenol

HRID 889267ノート

反応式

HRID 889267 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[OH:10].[N+:11]([O-])([OH:13])=[O:12]>S([O-])([O-])(=O)=O.[Ni+].[NH4+].ClCCl>[Br:1][C:2]1[C:3]([OH:10])=[C:4]([N+:11]([O-:13])=[O:12])[C:5]([F:9])=[C:6]([F:8])[CH:7]=1

参加物

5

反応物 2

HCID 944Nitric AcidHCID 27362882-Bromo-4,5-difluorophenol

生成物 1

HCID 840832366-Bromo-3,4-difluoro-2-nitrophenol

試薬・触媒・溶媒 2

HCID 171000000CID 171000000触媒HCID 6344Dichloromethane溶媒

実験手順

To a round bottom flask containing 2-bromo-4,5-difluorophenol (2.7 g, 12.9 mmol) and ammonium nickel sulfate (2.6 g, 6.46 mmol) is added dichloromethane (15 mL) at RT. A solution of 70% nitric acid (1.2 ml) is added dropwise and the slurry is stirred for 20 to 30 min. The mixture is then quenched with excess MgSO4, filtered and concentrated. The product is used in the next step without purification.

後処理

  1. customThe mixture is then quenched with excess MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe product is used in the next step without purification

出典と根拠

ORDレコード
ord-c98db8f863d24904825e49ce9dc520a8
出典データセット
uspto-grants-2012_08
特許番号
US08252820B2

反応ノート

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