Ethyl Acetate → 2-(4-Amino-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester

HRID 889388ノート

反応式

HRID 889388 の反応式
[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([F:18])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2].[H][H].C(OCC)(=O)C>[Pd].C(O)C>[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([F:18])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2]

参加物

6

反応物 3

HCID 8857Ethyl AcetateHCID 671311902-(3-Fluoro-4-nitro-phenoxy)-2-methyl-propionic acid ethyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 671309762-(4-Amino-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester収率 127.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

10% Palladium on carbon (200 mg) was added to a solution of 2-(3-fluoro-4-nitro-phenoxy)-2-methyl-propionic acid ethyl ester (1.15 g, 4 mmol) in ethanol (20 ml). The suspension was hydrogenated at a hydrogen gas pressure of 1.7 bar for 8 h at ambient temperature. Ethyl acetate was added (100 ml), the solid was filtered off and the filtrate was brought to dryness under reduced pressure to give the title compound (1.23 g, quant.) which was used in the next step without further purification.

後処理

  1. filtrationthe solid was filtered off

出典と根拠

ORDレコード
ord-29fdff4180c44d04a2fa9ba52ba5d2e7
出典データセット
uspto-grants-2012_08
特許番号
US08252826B2

反応ノート

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