Thionyl Chloride → 3-Cyclopentyl-2-phenylpropionyl chloride

HRID 889600ノート

反応式

HRID 889600 の反応式
[CH:1]1([CH2:6][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](O)=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:19])=O>CN(C=O)C>[CH:1]1([CH2:6][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([Cl:19])=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 186266423-Cyclopentyl-2-phenylpropanoic acid

生成物 1

HCID 866254663-Cyclopentyl-2-phenylpropionyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

実験手順

To the title B compound, 3-cyclopentyl-2-phenylpropionic acid (3.1 g, 14.2 mmol) is added 10 mL of thionyl chloride and one drop of DMF. The reaction mixture is stirred at ambient temperature for 2 h. The excess thionyl chloride is evaporated and the residue is twice treated with toluene and evaporated to yield 3-cyclopentyl-2-phenylpropionyl chloride as an orange-yellow oil which is selected as such without further purification.

後処理

  1. customThe excess thionyl chloride is evaporated
  2. additionthe residue is twice treated with toluene
  3. customevaporated

出典と根拠

ORDレコード
ord-6b5f13eb86734be696b006115b1e12de
出典データセット
uspto-grants-2012_08
特許番号
US08252931B2

反応ノート

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