4-(Benzyloxy)-1-(cyclopropylmethyl)pyridin-2(1H)-one → 1-(Cyclopropylmethyl)-4-hydroxypyridin-2(1H)-one
反応式
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C:11](=[O:19])[CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[CH:16]1([CH2:15][N:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]2=[O:19])[CH2:17][CH2:18]1参加物
4
実験手順
A mixture of intermediate D1 (2.0 g, 7.83 mmol) and a catalytic amount of 10% palladium on activated carbon in ethanol (300 ml) was stirred under a hydrogen atmosphere for two hours. The mixture was filtered through diatomaceous earth and the solvent was evaporated in vacuo to yield intermediate D2 (1.3 g, 100%) that was used without further purification.
後処理
- filtrationThe mixture was filtered through diatomaceous earth
- customthe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-73965e427c3440188ac1fce61090a170
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08252937B2
反応ノート
読み込み中…