Methanesulfinyl chloride → HCID 58545437、化合物

HRID 889662

反応式

HRID 889662 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][CH:3]=1.[CH3:10][S:11](Cl)=[O:12]>O1CCCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][S:11]([CH3:10])=[O:12])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 548463Methanesulfinyl chlorideHCID 70209275-(Aminomethyl)-2-chloropyridine

生成物 1

HCID 58545437HCID 58545437、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methanesulfinyl chloride was obtained as described in the literature. A solution of C-(6-chloro-pyridin-3-yl)-methylamine (2.1) (25 g, 178 mmol) in tetrahydrofuran (200 ml) was cooled to 0° C. and methanesulfinyl chloride (7 g, 71 mmol) was added dropwise. The solution was allowed to warm to room temperature and stirred for 16 hours. The precipitate was removed by filtration, the filtrate was diluted with EtOAc and washed with H2O. The organic phase was dried over Na2SO4 and evaporated under reduced pressure.

後処理

  1. customThe precipitate was removed by filtration
  2. additionthe filtrate was diluted with EtOAc
  3. washwashed with H2O
  4. dry with materialThe organic phase was dried over Na2SO4
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-3be19a7127c34e83a55bdf5cf018e576
出典データセット
uspto-grants-2012_08
特許番号
US08252939B2

関連ノート

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