Ethanol → Pactimibe

HRID 889789ノート

反応式

HRID 889789 の反応式
[CH2:1]([N:9]1[C:17]2[C:12](=[C:13]([CH3:29])[C:14](OCC)=[C:15]([CH3:25])[C:16]=2[NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:11][CH:10]1CC(O)=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH-:34].[Na+].[CH3:36][CH2:37][OH:38]>O>[CH2:1]([N:9]1[C:17]2[C:12](=[C:13]([CH3:29])[C:14]([CH2:36][C:37]([OH:34])=[O:38])=[C:15]([CH3:25])[C:16]=2[NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:11][CH2:10]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 69629575N-(1-octyl-5-ethoxycarboxymethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide

生成物 1

HCID 3081927Pactimibe

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

N-(1-octyl-5-ethoxycarboxymethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide (3.5 g) was dissolved in EtOH (50 ml) and a solution of NaOH (1.6 g) in water (20 ml) was added, which was followed by stirring at 60° C. for 1 hr. EtOH was evaporated under reduced pressure. The residue was dissolved in water (20 ml) and the mixture was washed with AcOEt (20 ml). The aqueous layer was neutralized with 2N-hydrochloric acid and extracted with AcOEt (50 ml). The AcOEt layer was washed with saturated brine and dried over anhydrous sodium sulfate. AcOEt was evaporated under reduced pressure to give 2.4 g of the title compound.

後処理

  1. customEtOH was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in water (20 ml)
  3. washthe mixture was washed with AcOEt (20 ml)
  4. extractionextracted with AcOEt (50 ml)
  5. washThe AcOEt layer was washed with saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. customAcOEt was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-1298b7f2e77c472697c01440f23c54c0
出典データセット
uspto-grants-2006_02
特許番号
USRE038970E1

反応ノート

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