Hydrochloric Acid → 6-(4-Chlorophenyl)-1,2,4-triazin-3-one

HRID 889823ノート

反応式

HRID 889823 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][NH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[N+](C1C=C(S([O-])(=O)=O)C=CC=1)([O-])=O.[Na+].[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[N:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 31389Sodium 3-nitrobenzenesulfonateHCID 691185446-(4-Chlorophenyl)-4,5-dihydro-1,2,4-triazin-3-one

生成物 1

HCID 222487986-(4-Chlorophenyl)-1,2,4-triazin-3-one収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3.64 g (17.4 mmol) of 6-(4-chlorophenyl)-4,5-dihydro-1,2,4-triazin-3-one, 4.0 g of sodium m-nitrobenzene sulfonate (17.8 mmol), 6.0 g of 50% sodium hydroxide (75.2 mmol) and 160 mL of water were refluxed overnight. The reaction mixture was cooled, then 1N aqueous HCl was added until the pH was slightly acidic to paper. The product was filtered, washed with water and dried to give 3.0 g of 6-(4-chlorophenyl)-1,2,4-triazin-3-one, which was used without further purification.

後処理

  1. temperaturewere refluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe product was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-9d533606d6fe4d94b682627da06b647e
出典データセット
uspto-grants-2006_02
特許番号
US06995157B2

反応ノート

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