2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 22249950、化合物

HRID 890212ノート

反応式

HRID 890212 の反応式
C(C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N.[Br:15][C:16]1[C:17]2[CH:43]=[CH:42][CH:41]=[CH:40][C:18]=2[O:19][C:20]=1[C:21]1[C:22]([CH3:39])=[N:23][N:24]2[C:29]3[N:30]([CH:33]([CH2:36][CH3:37])[CH2:34][CH3:35])[CH2:31][CH2:32][C:28]=3[C:27]([CH3:38])=[N:26][C:25]=12>C(Cl)Cl>[Br:15][C:16]1[C:17]2[CH:43]=[CH:42][CH:41]=[CH:40][C:18]=2[O:19][C:20]=1[C:21]1[C:22]([CH3:39])=[N:23][N:24]2[C:29]3[N:30]([CH:33]([CH2:34][CH3:35])[CH2:36][CH3:37])[CH:31]=[CH:32][C:28]=3[C:27]([CH3:38])=[N:26][C:25]=12

参加物

4

反応物 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 22249795HCID 22249795、化合物

生成物 1

HCID 22249950HCID 22249950、化合物収率 68.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

DDQ (33 mg, 0.15 mmol) was added to a solution of 3-(3-bromobenzo[b]furan-2-yl)-8-(1-ethylpropyl)-2,5-dimethyl-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine (60 mg, 0.13 mmol) in methylene chloride (10 mL) at room temperature, followed by stirring for one hour. After overnight, the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (40 mg) as a reddish brown oil.

後処理

  1. waitAfter overnight
  2. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-0294b9c7078e4a1fa7c5f5804ffe0332
出典データセット
uspto-grants-2006_02
特許番号
US06995163B2

反応ノート

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