Acrylonitrile → HCID 22250584、化合物

HRID 890247ノート

反応式

HRID 890247 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([CH3:11])=[CH:7]2.[C:12](#[N:15])[CH:13]=[CH2:14]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:14][CH2:13][C:12]#[N:15])[C:8]([CH3:11])=[CH:7]2

参加物

4

反応物 2

HCID 7855AcrylonitrileHCID 118160627-chloro-2-methyl-1H-indole

生成物 1

HCID 22250584HCID 22250584、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

反応条件

温度
60 °C

実験手順

20 g of 7-chloro-2-methyl-1H-indole are mixed in 100 ml of dioxane with 3 g of triton B, 3 g of acrylonitrile are slowly added, 250 ml of dioxane are added again and then the mixture is heated at 60° C. for 2 hours. The medium is evaporated and then the residue is taken up in AcOEt. The precipitate formed being removed, the product obtained is used as is in the following stage.

後処理

  1. additionare slowly added
  2. customThe medium is evaporated
  3. customThe precipitate formed
  4. custombeing removed
  5. customthe product obtained

出典と根拠

ORDレコード
ord-ba29b17d0fe24ef58b35fa9cc419cc88
出典データセット
uspto-grants-2006_02
特許番号
US06995184B2

反応ノート

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