4-Phenylcyclohexanone → 4-Phenylcyclohexanone oxime
反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+]>C(O)C.O>[OH:16][N:15]=[C:10]1[CH2:11][CH2:12][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1参加物
6
反応条件
- 温度
- 70 °C
実験手順
A mixture of 4-phenylcyclohexanone (28.7 mmol), hydroxylamine hydrochloride (36.0 mmol), and sodium acetate (60.95 mmol) in ethanol and water was heated at 70° C. overnight. Ethanol was removed, and the residue was dissolved in water and ethyl acetate. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried, and concentrated to give 1-(hydroxyimino)-4-phenylcyclohexane (97%).
後処理
- customEthanol was removed
- dissolutionthe residue was dissolved in water
- extractionThe aqueous layer was extracted with ethyl acetate
- washThe combined organic layers were washed with brine
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-d1c6e62fd48849e89adc22db2d64dcf8
- 出典データセット
- uspto-grants-2006_02
- 特許番号
- US06995269B2
反応ノート
読み込み中…