Chloroacetyl chloride → HCID 2063649、化合物
反応式
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].C(N(CC)CC)C.[Cl:19][CH2:20][C:21](Cl)=[O:22]>C(Cl)Cl>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][N:9]([C:21]([CH2:20][Cl:19])=[O:22])[CH2:10][CH2:11]1)=[O:5])[CH3:2]参加物
5
実験手順
To a solution of 1-ethoxycarbonylpiperazine (1.5 mL, 10 mmol) in 40 mL CH2Cl2, was added triethylamine (2 mL, 14 mmol) and chloroacetyl chloride (0.8 mL, 5.0 mmol) at 0° C. The resulting reaction mixture was stirred at amibent temperature for 2 hours. The reaction mixture was washed with water, 2N NaHSO4 and brine, and dried over sodium sulfate. The solvent was evaporated in vacuo to afford 1-ethoxycarbonyl-4-chloromethylcarbonylpiperazine (4.5 g) as an yellow oil, which was used without further purification.
後処理
- customThe resulting reaction mixture
- washThe reaction mixture was washed with water, 2N NaHSO4 and brine
- dry with materialdried over sodium sulfate
- customThe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-aa7bf3bac64a4f76a7cb9f34304a742c
- 出典データセット
- uspto-grants-2006_02
- 特許番号
- US06995156B2
反応ノート
読み込み中…