Lithium Hydroxide → {6-[2-Methyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid
反応式
C([O:3][C:4](=[O:39])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[C:18]([CH3:38])=[N:19][C:20]([C:27]4[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=4)=[CH:21][C:22]=3[C:23]([F:26])([F:25])[F:24])[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH3:38][C:18]1[C:17]([CH2:16][O:15][C:12]2[CH:13]=[C:14]3[C:9]([CH:8]=[CH:7][N:6]3[CH2:5][C:4]([OH:39])=[O:3])=[CH:10][CH:11]=2)=[C:22]([C:23]([F:25])([F:26])[F:24])[CH:21]=[C:20]([C:27]2[CH:32]=[CH:31][C:30]([O:33][C:34]([F:36])([F:35])[F:37])=[CH:29][CH:28]=2)[N:19]=1参加物
3
実験手順
In analogy to the procedure described in example 5 g], {6-[2-methyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain the title compound as colorless solid.
出典と根拠
- ORDレコード
- ord-20e57c7176964e43a811b70f23344dc7
- 出典データセット
- uspto-grants-2006_02
- 特許番号