Chloroform → 3,3-Dichloropiperidin-2-one
反応式
[C:1]1(=[O:7])[NH:6][CH2:5][CH2:4][CH2:3]C1.P(Cl)(Cl)(Cl)(Cl)Cl.[CH:14]([Cl:17])(Cl)[Cl:15]>>[Cl:15][C:14]1([Cl:17])[CH2:3][CH2:4][CH2:5][NH:6][C:1]1=[O:7]参加物
4
実験手順
Part A. To valerolactam (5.6 g, 55 mmol) in CHCl3 was added PCl5 (34.6 g, 166 mmol) and the reaction was heated to reflux 24 h. The reaction was cooled, quenched with H2O, extracted with CHCl3 and dried (MgSO4) to afford crude 3,3-dichloro-2-piperidinone.
後処理
- temperaturethe reaction was heated
- temperatureto reflux 24 h
- temperatureThe reaction was cooled
- customquenched with H2O
- extractionextracted with CHCl3
- dry with materialdried (MgSO4)
出典と根拠
- ORDレコード
- ord-94bda8a7855946abbd901a19596d9257
- 出典データセット
- uspto-grants-2006_02
- 特許番号
- US06995172B2
反応ノート
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