4-Methylmorpholine → 2-acetyl-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}octanamide
反応式
[C:1]([CH:4]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[C:5]([O:7]C)=O)(=[O:3])[CH3:2].C(C(CCCCCC)C(O)=O)(=O)C.ON1C2C=CC=CC=2N=N1.CN1CCOCC1.Cl.CN(C)CCCN=C=NCC.[NH2:57][CH:58]([C:60]1[C:61](=[O:77])[NH:62][C:63]([CH2:66][C:67]2[CH:72]=[CH:71][C:70]([O:73][CH3:74])=[C:69]([O:75][CH3:76])[CH:68]=2)=[N:64][N:65]=1)[CH3:59]>ClCCl>[C:1]([CH:4]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[C:5]([NH:57][CH:58]([C:60]1[C:61](=[O:77])[NH:62][C:63]([CH2:66][C:67]2[CH:72]=[CH:71][C:70]([O:73][CH3:74])=[C:69]([O:75][CH3:76])[CH:68]=2)=[N:64][N:65]=1)[CH3:59])=[O:7])(=[O:3])[CH3:2]参加物
8
反応物 6
HCID 79724-Methylmorpholine
HCID 757711-Hydroxybenzotriazole
HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride
HCID 3390996Methyl 2-acetyloctanoate
HCID 187645892-Acetyloctanoic acid
HCID 1356979236-(1-Aminoethyl)-3-[(3,4-dimethoxyphenyl)methyl]-1,2,4-triazin-5(2H)-one生成物 1
試薬・触媒・溶媒 1
実験手順
601 g (3.0 mmol) of methyl 2-acetyloctanoate (Example 18A) are hydrolysed to 2-acetyloctanoic acid according to Example 19A. The acid in 20 ml of dichloromethane is reacted analogously to Example 23A with 1.08 g (8.0 mmol) of 1-hydroxy-1H-benzotriazole, 1.62 g (16.0 mmol) of 4-methylmorpholine, 1.53 g (8.0 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 870 mg (3.0 mmol) of 6-(1-aminoethyl)-3-(3,4-methoxybenzyl)-1,2,4-triazin-5(4H)-one (Example 12A) to give 2-acetyl-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}octanamide.
出典と根拠
- ORDレコード
- ord-3a8e0c76393c4da086040d9dd3858040
- 出典データセット
- uspto-grants-2006_02
- 特許番号
- US06998402B2
反応ノート
読み込み中…