5-Methyl-2-pyridinesulfonamide → N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-5-methyl-2-pyridinesulfonamide

HRID 891095

反応式

HRID 891095 の反応式
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[CH3:32][C:33]1[CH:34]=[CH:35][C:36]([S:39]([NH2:42])(=[O:41])=[O:40])=[N:37][CH:38]=1>>[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:42][S:39]([C:36]3[CH:35]=[CH:34][C:33]([CH3:32])=[CH:38][N:37]=3)(=[O:41])=[O:40])=[O:24])=[CH:18][CH:19]=2)[N:3]=1

参加物

3

反応物 2

HCID 36141995-Methyl-2-pyridinesulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

生成物 1

HCID 22244663N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-5-methyl-2-pyridinesulfonamide

実験手順

The title compound was prepared according to the procedure described in step 2 of Example 22 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 5-methyl-2-pyridinesulfonamide: 1H-NMR (CDCl3) δ 8.47 (1H, s), 7.90 (1H, d, J=7.9 Hz), 7.73 (1H, d, J=7.9 Hz), 7.47-7.24 (9H, m), 6.68 (1H, br.s), 3.54-3.44 (2H, m), 2.88-2.83 (2H, m), 2.43 (3H, s), 2.33 (3H, s), 2.27 (3H, s).

出典と根拠

ORDレコード
ord-9686ca476a2a4096aaa80baddac6e3e2
出典データセット
uspto-grants-2006_02
特許番号
US07001917B2

関連ノート

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