Lithium Hydroxide → {3-[(Isoquinolin-1-carbonyl)amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl} acetic acid

HRID 891190ノート

反応式

HRID 891190 の反応式
C[O:2][C:3](=[O:26])[CH2:4][N:5]1[CH2:11][CH:10]=[CH:9][CH2:8][CH:7]([NH:12][C:13]([C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][N:16]=2)=[O:14])[C:6]1=[O:25].[Li+].[OH-]>C1COCC1.O>[C:15]1([C:13]([NH:12][CH:7]2[CH2:8][CH:9]=[CH:10][CH2:11][N:5]([CH2:4][C:3]([OH:26])=[O:2])[C:6]2=[O:25])=[O:14])[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][N:16]=1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 23598688{3-[(Isoquinolin-1-carbonyl)amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl} acetic acid methyl ester

生成物 1

HCID 23598657{3-[(Isoquinolin-1-carbonyl)amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl} acetic acid

試薬・触媒・溶媒 1

HCID 21881883Oxolane--water (1/1)溶媒

実験手順

A solution of {3-[(isoquinolin-1-carbonyl)amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl} acetic acid methyl ester, 4, (330 mg, 0.9 mmol) in 3:1 THF/H2O is treated with excess LiOH (360 mg, 8.6 mmol) and stirred for 2.5 hours at room temperature. The solution is then acidified and the aqueous layer extracted with EtOAc. The EtOAc layer is dried (MgSO4) and concentrated in vacuo to afford the desired product.

後処理

  1. extractionthe aqueous layer extracted with EtOAc
  2. dry with materialThe EtOAc layer is dried (MgSO4)
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-9c5514792bd54bc89457262b84e5ef7c
出典データセット
uspto-grants-2006_02
特許番号
US07001899B2

反応ノート

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