Methyl 2-methyl-6-nitrobenzoate → Benzoic acid, 2-amino-6-methyl-, methyl ester

HRID 891265

反応式

HRID 891265 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[C:3]=1[C:4]([O:6][CH3:7])=[O:5]>CO.[Pd]>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([NH2:12])[C:3]=1[C:4]([O:6][CH3:7])=[O:5]

参加物

4

反応物 1

HCID 596057Methyl 2-methyl-6-nitrobenzoate

生成物 1

HCID 583916Benzoic acid, 2-amino-6-methyl-, methyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-Methyl-6-nitrobenzoic acid is reacted with trimethylsilyldiazomethane to yield methyl 2-methyl-6-nitrobenzoate with m.p. 44–45° (Chem. Pharm. Bull., Vol. 29, 1475 (1981)). Methyl 2-methyl-6-nitrobenzoate is hydrogenated in methanol in the presence of palladium, 10% on carbon powder, at room temperature and atmospheric pressure to give methyl 2-methyl-6-aminobenzoate.

出典と根拠

ORDレコード
ord-b03d0cdcce9948cdb713843722b25123
出典データセット
uspto-grants-2006_02
特許番号
US07002022B2

関連ノート

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