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Diethyl Sulfate → 2-Bromo-7-ethoxynaphthalene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Sulfate | HCID 6163 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 7-Bromo-2-naphthol | HCID 613827 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-Bromo-7-ethoxynaphthalene | HCID 22240149 | 89% |
反応手順
To a solution of 7-bromo-naphth-2-ol (1.0 g, 4.5 mmol, prepared according to patent WO 0146187 A1) in acetonitrile (10 ml) was added diethyl sulfate (1.04 g, 6.7 mmol), K2CO3 (0.92 g) and tetrabutylammonium bromide (10 mg). The reaction mixture was refluxed for 1 hour, poured on water and extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and the solvent was removed under reduced pressure to provide 2-bromo-7-ethoxynaphthalene (89%), MS: m/e=252 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07005432B2 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-258293cb967e432aaa11dcbe01b4630c |
| 出典メモ | uspto-grants-2006_02 |