反应详情

To a solution of 7-bromo-naphth-2-ol (1.0 g, 4.5 mmol, prepared according to patent WO 0146187 A1) in acetonitrile (10 ml) was added diethyl sulfate (1.04 g, 6.7 mmol), K2CO3 (0.92 g) and tetrabutylammonium bromide (10 mg). The reaction mixture was refluxed for 1 hour, poured on water and extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and the solvent was removed under reduced pressure to provide 2-bromo-7-ethoxynaphthalene (89%), MS: m/e=252 (M+).

1. temperatureThe reaction mixture was refluxed for 1 hour
2. additionpoured on water
3. extractionextracted with CH2Cl2
4. dry with materialThe combined organic layers were dried over MgSO4
5. filtrationfiltered
6. customthe solvent was removed under reduced pressure