6-(6-cyano-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-pyridinecarboxylic acid → 6-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-pyridinecarboxylic acid

HRID 892558ノート

反応式

HRID 892558 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:11][C:10]([CH3:13])([CH3:12])[CH:9]=[C:8]([C:14]3[N:19]=[CH:18][C:17]([C:20]([OH:22])=[O:21])=[CH:16][CH:15]=3)[C:7]=2[CH:23]=1)#[N:2]>C(OCC)(=O)C.[Pd]>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:11][C:10]([CH3:13])([CH3:12])[CH2:9][CH:8]([C:14]3[N:19]=[CH:18][C:17]([C:20]([OH:22])=[O:21])=[CH:16][CH:15]=3)[C:7]=2[CH:23]=1)#[N:2]

参加物

4

反応物 1

HCID 198956976-(6-cyano-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-pyridinecarboxylic acid

生成物 1

HCID 198956946-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-pyridinecarboxylic acid収率 48.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

1.4 g of 6-(6-cyano-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-pyridinecarboxylic acid were dissolved in 200 ml of ethyl acetate and shaken under a hydrogen atmosphere overnight with 103 mg of 10% palladium-on-charcoal. The mixture was filtered and the filtrate was evaporated. There were obtained 680 mg of 6-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-pyridinecarboxylic acid which was used without further purification.

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-9b71a61b31da41a0a2ec3c30a84a674d
出典データセット
uspto-grants-1992_06
特許番号
US05118694

反応ノート

読み込み中…