Benzaldehyde → 5-Benzylidene-2,4-thiazolidinedione

HRID 892826

反応式

HRID 892826 の反応式
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:9]1[CH2:13][C:12](=[O:14])[NH:11][C:10]1=[O:15]>N1C=CC=CC=1.CN(C)C=O.CCCCCC.O>[C:2]1([CH:1]=[C:13]2[S:9][C:10](=[O:15])[NH:11][C:12]2=[O:14])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 2

HCID 240BenzaldehydeHCID 5437Thiazolidinedione

生成物 1

HCID 1991545-Benzylidene-2,4-thiazolidinedione収率 109.3%

試薬・触媒・溶媒 4

HCID 962Water溶媒HCID 1049Pyridine溶媒HCID 6228Dimethylformamide溶媒HCID 8058Hexane溶媒

反応条件

温度
55 °C

実験手順

Benzaldehyde (0.78 mol, 82.8 g) and 2,4-thiazolidinedione (0.85 mol, 100 g) were heated to reflux in a mixture of pyridine (215 ml) and dimethylformamide (400 ml) for 18 hours. The reaction mixture was cooled to 55° C. and diluted with hexane (360 ml) and water (900 ml) and stirred for 1 hour after cooling to room temperature. The product was collected to afford 175 g of pale yellow solid; m.p. 246°-248° C.

後処理

  1. temperatureafter cooling to room temperature
  2. customThe product was collected

出典と根拠

ORDレコード
ord-9d7197d11b224038a55a54a8f9b98ee7
出典データセット
uspto-grants-1992_06
特許番号
US05120754

関連ノート

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