1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → N-[2-(Oleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide

HRID 892890ノート

反応式

HRID 892890 の反応式
Cl.C(N=C=NCCCN(C)C)C.[C:13]([NH:32][C:33]1[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=1[NH2:35])(=[O:31])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]/[CH:21]=[CH:22]\[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30].[CH3:40][C:41]1([CH3:57])[O:46][CH:45]([C:47]([NH:49][CH2:50][CH2:51][C:52](O)=[O:53])=[O:48])[C:44]([CH3:56])([CH3:55])[CH2:43][O:42]1>C(Cl)Cl>[C:13]([NH:32][C:33]1[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=1[NH:35][C:52](=[O:53])[CH2:51][CH2:50][NH:49][C:47]([CH:45]1[C:44]([CH3:55])([CH3:56])[CH2:43][O:42][C:41]([CH3:57])([CH3:40])[O:46]1)=[O:48])(=[O:31])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]/[CH:21]=[CH:22]\[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]

参加物

5

反応物 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 189385173-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acidHCID 42604663o-Oleoylaminoaniline

生成物 1

HCID 67796153N-[2-(Oleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide収率 82%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (211 mg) was added to a solution of 372 mg of 2-oleoylaminoaniline and 259 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid in 30 ml of methylene chloride under ice cooling. The mixture was stirred in situ for one night. The reaction mixture was washed with water and dried over anhydrous sodium sulfate, filtered and the filtate evaporation under vacuum to obtain the crude title products. Then, the residue obtained was subjected to silica gel column chromatography to obtain 500 mg of the title compound (yield: 82%).

後処理

  1. washThe reaction mixture was washed with water
  2. dry with materialdried over anhydrous sodium sulfate
  3. filtrationfiltered
  4. customthe filtate evaporation under vacuum
  5. customto obtain the crude title products
  6. customThen, the residue obtained

出典と根拠

ORDレコード
ord-79dd72c185834bb6be6210b6151eb400
出典データセット
uspto-grants-1992_06
特許番号
US05120738

反応ノート

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