Isobutyraldehyde → HCID 14849775、化合物

HRID 892953ノート

反応式

HRID 892953 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)=[CH:4][CH:3]=1.C([O-])(=O)C.[NH4+:22].[CH:23](=O)[CH:24]([CH3:26])[CH3:25].[OH-].[NH4+:29]>C(O)(=O)C.C(OC(=O)C)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:29][C:23]([CH:24]([CH3:26])[CH3:25])=[N:22][C:9]=2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 6561IsobutyraldehydeHCID 14923Ammonium HydroxideHCID 517165Ammonium AcetateHCID 36253104-Fluorobenzil

生成物 1

HCID 14849775HCID 14849775、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 7918Acetic Anhydride溶媒

実験手順

To a stirred solution of 1-(4-fluorophenyl)-2-phenylethan-1,2-dione (1.0 g) in acetic acid (25 ml) and acetic anhydride (3 ml) containing ammonium acetate (5.0 g) was added isobutyraldehyde (0.5 g) and the reaction mixture was warmed to 110° for 2 h. The mixture was poured into aqueous ammonium hydroxide at 0° and the deposited solid was collected by filtration, then washed sequentially with ether and water then dried in vacuo to afford the title compound (1.09 g), λmax (EtOH) 252 (9550) and 287.8 nm (ε11,870).

後処理

  1. temperaturethe reaction mixture was warmed to 110° for 2 h
  2. filtrationthe deposited solid was collected by filtration
  3. washwashed sequentially with ether and water
  4. customthen dried in vacuo

出典と根拠

ORDレコード
ord-49ab51c2bb1649549c7a12595f58576b
出典データセット
uspto-grants-1992_06
特許番号
US05120848

反応ノート

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