Methyl iodide → HCID 86745908、化合物

HRID 893004ノート

反応式

HRID 893004 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:10][CH:11]=[CH2:12])[CH:5]=[C:6]([CH3:9])[C:7]=1[OH:8].[OH-].[K+].I[CH3:16]>CS(C)=O>[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH3:12])[CH:5]=[C:6]([CH3:9])[C:7]=1[O:8][CH3:16]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 124349732,6-Dimethyl-4-(prop-2-en-1-yl)phenol

生成物 1

HCID 86745908HCID 86745908、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

3-(3,5-Dimethyl-4-hydroxyphenyl)-1-propene (5.0 g) is added to a mixture of powdered potassium hydroxide (7.98 g) in dimethylsulfoxide (50 ml) at 15°. Iodomethane (8.8 ) is then added and stirred below 20° for 0.5 hr. The reaction mixture is poured into ice/water and the product is extracted with ether (2×). The ether extracts are washed with water (3×), saline, dried over sodium sulfate and concentrated under reduced pressure to give 3-(3,5-dimethyl-4-methoxyphenyl-1-propene. The "propene" is transformed to the corresponding "propanol" with borane-dimethylsulfide by the general procedure of PREPARATION NA-19 to give the title compound.

後処理

  1. extractionthe product is extracted with ether (2×)
  2. washThe ether extracts are washed with water (3×), saline
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d06ed4b6859f495e9e6ac69d5dc40009
出典データセット
uspto-grants-1992_06
特許番号
US05120843

反応ノート

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