Hydrochloric Acid → HCID 15728797、化合物

HRID 893262ノート

反応式

HRID 893262 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9]3=[C:10]([C:12](=[O:15])C(=O)[N:8]3[CH:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:6][CH2:5]2)[CH:11]=1.[OH-:22].[Na+].OO.Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([OH:22])=[O:15])[CH:11]=1)[NH:8][CH:7]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:6][CH2:5]2

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 19892016HCID 19892016、化合物

生成物 1

HCID 15728797HCID 15728797、化合物収率 96.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 8-chloro-5,6-dihydro-4-phenyl-4H-pyrrolo-[3,2,1-ij]quinoline-1,2-dione (3.4 g) and sodium hydroxide (2 g) in water (100 ml) was added 35% aqueous hydrogen peroxide solution (5 ml) and stirred at room temperature for an hour. The reaction mixture was acidified slightly by adding concentrated hydrochloric acid, the resulting precipitate was collected by filtration, washed and dried to give the title compound (3.17 g, 96.7%) as yellow crystals. This crystals was recrystallized from ethanol to pale yellow needles, mp 199°-200 ° C.

後処理

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed
  3. customdried

出典と根拠

ORDレコード
ord-7101be7001e7461697560143b706ac13
出典データセット
uspto-grants-1992_06
特許番号
US05124325

反応ノート

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