2-(4-Chlorophenylmethylamino)-5-fluoronitrobenzene → 2-(4-Chlorobenzylamino)-5-fluoroaniline

HRID 893350ノート

反応式

HRID 893350 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[N+:17]([O-])=O)=[CH:4][CH:3]=1>O1CCCC1.[Ni]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[NH2:17])=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 149529762-(4-Chlorophenylmethylamino)-5-fluoronitrobenzene

生成物 1

HCID 149529912-(4-Chlorobenzylamino)-5-fluoroaniline収率 91.6%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

41.7 g of 2-(4-chlorophenylmethylamino)-5-fluoronitrobenzene, prepared in Example 1, re dissolved in 1 l of tetrahydrofuran and hydrogenated at ordinary temperature and pressure in the presence of 5 g of Raney nickel. When the theoretical amount of hydrogen has been absorbed, the catalyst is filtered off and the solvent is evaporated off under vacuum to give 34.1 g of 2-(4-chlorophenylmethylamino)-5-fluoroaniline in the form of crystals melting at 99° C.

後処理

  1. customWhen the theoretical amount of hydrogen has been absorbed
  2. filtrationthe catalyst is filtered off
  3. customthe solvent is evaporated off under vacuum

出典と根拠

ORDレコード
ord-c3c76779b5dd4dd59c30c78a71c617b1
出典データセット
uspto-grants-1992_06
特許番号
US05124336

反応ノート

読み込み中…