Lithium Hydroxide → HCID 15341834、化合物

HRID 893474ノート

反応式

HRID 893474 の反応式
[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[C:6]([CH2:31][CH:32]=[CH2:33])[C:5]=1[O:34][CH3:35])=[O:3].[OH-].[Li+]>CO>[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:6]([CH2:31][CH:32]=[CH2:33])[C:5]=1[O:34][CH3:35])=[O:3]

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 15341833HCID 15341833、化合物

生成物 1

HCID 15341834HCID 15341834、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The compound of Example 55 (100 mg, 0.195 mmol) and 390 μl of 1 M lithium hydroxide (0.3896 mmol) were added to 2.0 ml of methanol, and the reaction mixture was stirred at room temperature for 4 hours. The solvent was removed under vacuum, 5.0 ml of water was added to the residue, and the mixture was acidified with 10% hydrochloric acid. The mixture was filtered, and the white solid which was recovered was dried in a 40° C. oven overnight to give the product.

後処理

  1. customThe solvent was removed under vacuum, 5.0 ml of water
  2. additionwas added to the residue
  3. filtrationThe mixture was filtered
  4. customthe white solid which was recovered
  5. customwas dried in a 40° C. oven overnight
  6. customto give the product

出典と根拠

ORDレコード
ord-d903b85a75c84494a26076e615d488ce
出典データセット
uspto-grants-1992_06
特許番号
US05124350

反応ノート

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