Methanol → HCID 19890426、化合物

反応式

[OH-].[Na+].CO.[F:5][C:6]([F:27])([F:26])[CH:7]([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:8][CH2:9][O:10][C:11]1[CH:21]=[CH:20][C:14]([C:15]([O:17]CC)=[O:16])=[CH:13][CH:12]=1>O>[F:5][C:6]([F:26])([F:27])[CH:7]([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:8][CH2:9][O:10][C:11]1[CH:21]=[CH:20][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=1

参加物

反応条件

温度: 50 °C

実験手順

0.082 g of sodium hydroxide was dissolved in 1 ml of water, followed by addition of 3 ml of methanol and 0.22 g of ethyl p-(3-trifluoromethylheptyloxy)-benzoate and 3 hours of stirring at 50° C. After the reaction, water was added, methanol was removed by distillation under a reduced pressure, and 6N-hydrochloric acid was added to precipitate a crystal. The crystal was recovered by filtration, washed with water and dried to obtain 0.15 g (yield: 76%) of p-(3-trifluoromethylheptyloxy)benzoic acid, which showed: [α]D24 +4.2, [α]43525 +8.6 (c 1.00, CHCl3).