Hydrochloric Acid → 3-(2-Hexyl-4-tetradecylphenoxy)-1,2-propanediol

HRID 893591

反応式

HRID 893591 の反応式
[CH2:1]([C:7]1[CH:21]=[C:20]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:19]=[CH:18][C:8]=1[O:9][CH2:10][CH:11]1[CH2:15][O:14]C(C)(C)[O:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].Cl>O1CCCC1>[CH2:1]([C:7]1[CH:21]=[C:20]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:19]=[CH:18][C:8]=1[O:9][CH2:10][CH:11]([OH:12])[CH2:15][OH:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 148196694-((2-Hexyl-4-tetradecylphenoxy)methyl)-2,2-dimethyl-1,3-dioxolane

生成物 1

HCID 148196703-(2-Hexyl-4-tetradecylphenoxy)-1,2-propanediol収率 98.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 13.6 g of 4-((2-hexyl-4-tetradecylphenoxy)methyl)-2,2-dimethyl-1,3-dioxolane, 10 ml of 5% hydrochloric acid and 250 ml of tetrahydrofuran was heated at reflux for 4 hours, then allowed to cool and the tetrahydrofuran removed under reduced pressure. The mixture was then extracted several times with ethyl acetate. The organic extracts were combined, washed with aqueous sodium bicarbonate, dried and the solvent evaporated, giving 12.3 g of the desired compound.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours
  3. temperatureto cool
  4. customthe tetrahydrofuran removed under reduced pressure
  5. extractionThe mixture was then extracted several times with ethyl acetate
  6. washwashed with aqueous sodium bicarbonate
  7. customdried
  8. customthe solvent evaporated

出典と根拠

ORDレコード
ord-3047b75749ef4c48a3ca6dd5c6dcd8a9
出典データセット
uspto-grants-1992_06
特許番号
US05126291

関連ノート

読み込み中…