Ethanol → 4-phenyl-1H-pyrrole-2-carboxylic acid

HRID 894078ノート

反応式

HRID 894078 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:13]([OH:15])=[O:14])[NH:11][CH:12]=2)=[CH:4][CH:3]=1.C(O)C>[Pd].C(N(CC)CC)C>[C:5]1([C:8]2[CH:9]=[C:10]([C:13]([OH:15])=[O:14])[NH:11][CH:12]=2)[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=1

参加物

5

反応物 2

HCID 702EthanolHCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid

生成物 1

HCID 128971004-phenyl-1H-pyrrole-2-carboxylic acid収率 78.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8471Triethylamine溶媒

実験手順

4-(4-Chlorophenyl)pyrrole-2-carboxylic acid (0.6 g.) was hydrogenated over 200 mg. of b 5% Pd/C in 50 ml. of ethanol for approximately 16 hours at 50 p.s.i. An additional 200 ml. of catalyst and 1 ml. of triethylamine was added and hydrogenation continued for 3 hours at 50 p.s.i. The catalyst was recovered by filtration, and the mother liquid concentrated to dryness to yield 4-phenylpyrrole-2-carboxylic acid [400 mg., m.p. 226°-228° C. (dec.), m/e 187]. For analysis, the product was recrystallized from acetone/hexane [240 mg., m.p. 227°-229° C. (dec.)].

後処理

  1. filtrationThe catalyst was recovered by filtration
  2. concentrationthe mother liquid concentrated to dryness

出典と根拠

ORDレコード
ord-769fe7a055fb49a7bf9bc5b6e9243861
出典データセット
uspto-grants-1981_08
特許番号
US04282242

反応ノート

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