Phenyl Isothiocyanate → N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea

HRID 894106ノート

反応式

HRID 894106 の反応式
C[O-].[Na+].I.[NH:5]=[C:6]1[N:10]([CH3:11])[CH2:9][CH2:8][S:7]1.[C:12]1([N:18]=[C:19]=[S:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(O)C>[CH3:11][N:10]1[CH2:9][CH2:8][S:7][C:6]1=[N:5][C:19]([NH:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[S:20]

参加物

5

反応物 3

HCID 7673Phenyl IsothiocyanateHCID 27705073-methyl-1,3-thiazolidin-2-imine HydroiodideHCID 10942334Sodium Methoxide

生成物 1

HCID 54546998N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Sodium methoxide (2.16 g) was added to a mixture of 2-imino-3-methylthiazolidine hydroiodide (10.0 g) in ethanol (50 ml) and brought to reflux, with stirring. Phenylisothiocyanate (5.4 g) in ethanol (20 ml) was added to the mixture over 5 minutes and the resultant mixture heated under reflux, with stirring, for one hour then cooled in ice. Filteration gave analytically pure product, mpt 169°-170°, which may be recrystallised from isopropanol.

後処理

  1. temperatureto reflux
  2. temperatureunder reflux
  3. stirringwith stirring, for one hour
  4. temperaturethen cooled in ice
  5. customFilteration gave analytically pure product, mpt 169°-170°, which
  6. custommay be recrystallised from isopropanol

出典と根拠

ORDレコード
ord-0ae1cf078ac74a84a51ed3f6d908f564
出典データセット
uspto-grants-1981_08
特許番号
US04282356

反応ノート

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