3-Allyl-4-methyl-4,5-epoxypentan-2-one → 2,4-Dimethyl-3-(prop-2-en-1-yl)furan

HRID 894157ノート

反応式

HRID 894157 の反応式
[CH2:1]([CH:4]([C:8]1([CH3:11])[O:10][CH2:9]1)[C:5](=O)[CH3:6])[CH:2]=[CH2:3]>C(=O)([O-])[O-].[Na+].[Na+]>[CH3:11][C:8]1[O:10][CH:9]=[C:5]([CH3:6])[C:4]=1[CH2:1][CH:2]=[CH2:3]

参加物

3

反応物 1

HCID 132086283-Allyl-4-methyl-4,5-epoxypentan-2-one

生成物 1

HCID 132086342,4-Dimethyl-3-(prop-2-en-1-yl)furan収率 45.3%

試薬・触媒・溶媒 1

HCID 10340Sodium Carbonate溶媒

実験手順

3-Allyl-4-methyl-4,5-epoxy-pentan-2-one (4.50 g) was added to a 1% aqueous sodium carbonate solution (150 ml), followed by stirring for 2 hours at a bath temperature of 60° to 65° C. The reaction solution was extracted three times with methylene chloride, and the methylene chloride layer was washed with an aqueous sodium chloride solution. After removing the solvent by evaporation, the residue was column chromatographed on silica gel (50 g) and developed with methylene chloride. From the first eluate (400 ml) was obtained 1.80 g of a pure objective 2,4-dimethyl-3-allylfuran.

後処理

  1. extractionThe reaction solution was extracted three times with methylene chloride
  2. washthe methylene chloride layer was washed with an aqueous sodium chloride solution
  3. customAfter removing the solvent
  4. customby evaporation
  5. customchromatographed on silica gel (50 g)

出典と根拠

ORDレコード
ord-6e38610a068c406181689ecfda0b98dd
出典データセット
uspto-grants-1981_08
特許番号
US04282372

反応ノート

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