Sodium Hydroxide → 2-(4-Bromophenoxymethyl)benzoic acid
反応式
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH2:7][C:8]2[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([O:12]C)=[O:11])=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([OH:12])=[O:11])=[CH:18][CH:19]=1参加物
4
実験手順
Reflux 90 gm. of the crude methyl o-(p-bromophenoxymethyl)benzoate from Step B for 1 hour in a mixture of 500 cc. of methanol and 250 cc. of 10% aqueous sodium hydroxide. Evaporate the methanol and dilute the resulting aqueous solution with an equal volume of water. Acidify with conc. hydrochloric acid. Separate the solids by filtration, wash with water and dry in vacuo to obtain the title product (m.p. 183°-185° C.).
後処理
- temperatureReflux 90 gm
- customEvaporate the methanol
- additiondilute the resulting aqueous solution with an equal volume of water
- customSeparate the solids
- filtrationby filtration
- washwash with water
- customdry in vacuo
出典と根拠
- ORDレコード
- ord-fe23260d7d594c14b618cde616bca14a
- 出典データセット
- uspto-grants-1981_08
- 特許番号
- US04282365
反応ノート
読み込み中…