Hydroxyphenylacetic acid → 2-(4-Hydroxyphenyl)-N-methylacetamide
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.C1[C:17]([N+:18]([O-])=O)=CC=C(O)C=1.C1(N=C=NC2CCCCC2)CCCCC1>C(#N)C>[CH3:17][NH:18][C:9](=[O:11])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1参加物
5
実験手順
To a solution of 7.6 g of p-hydroxyphenylacetic acid in 100 ml of acetonitrile were added 8.4 g of p-nitrophenol and 10.3 g of dicyclohexylcarbodiimide at room temperature with stirring, and the resulting crystals of dicyclohexylurea were filtered out. An ethereal solution of 7.8 g of methylamine was added to the filtrate containing p-nitrophenyl p-hydroxyphenylacetate, the mixture was allowed to stand to precipitate crystals. The crystals obtained were filtered out and washed with diethyl ether to obtain 4.0 g of the title compound.
後処理
- filtrationthe resulting crystals of dicyclohexylurea were filtered out
- additionAn ethereal solution of 7.8 g of methylamine was added to the filtrate
- additioncontaining p-nitrophenyl p-hydroxyphenylacetate
- customto precipitate crystals
- customThe crystals obtained
- filtrationwere filtered out
- washwashed with diethyl ether
出典と根拠
- ORDレコード
- ord-a876e0bd58734442ad69edd3678d3fd9
- 出典データセット
- uspto-grants-1981_08
- 特許番号
- US04283418
反応ノート
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