Acetic Acid → Cgp13501

HRID 894876

反応式

HRID 894876 の反応式
[C:1]([C:5]1[CH:10]=[C:9]([CH2:11]OC)[CH:8]=[C:7]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:6]=1[OH:18])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+].[CH:21](=[O:25])[CH:22]([CH3:24])[CH3:23].C(O)(=O)C>CO>[CH3:23][C:22]([CH3:24])([CH2:11][C:9]1[CH:10]=[C:5]([C:1]([CH3:2])([CH3:4])[CH3:3])[C:6]([OH:18])=[C:7]([C:14]([CH3:17])([CH3:15])[CH3:16])[CH:8]=1)[CH:21]=[O:25]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 6561IsobutyraldehydeHCID 69112,6-Di-tert-butyl-4-(methoxymethyl)phenolHCID 14797Potassium Hydroxide

生成物 1

HCID 3519541Cgp13501収率 98.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 25 grams (0.1 mole) of 2,6-di-tert.butyl-4-methoxymethylphenol and one gram (0.015 mole) of KOH in 100 milliliters of methanol was heated to 60° C. 9 grams (0.125 moles) of isobutyraldehyde was added to the solution during a period of 10 minutes and the reaction mixture was heated under reflux for 3 hours. After the mixture had cooled to room temperature it was poured into 125 milliliters of 1% acetic acid. The solid that precipitated was filtered off and allowed to dry. There was obtained 28.5 grams (98.2% of theory) of 2,2-dimethyl-3-(3,5-di-tert.butyl-4-hydroxyphenyl) propionaldehyde with a melting point of 72° to 74° C.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux for 3 hours
  3. customThe solid that precipitated
  4. filtrationwas filtered off
  5. customto dry

出典と根拠

ORDレコード
ord-25653be24e28448e82c7834bf56455b3
出典データセット
uspto-grants-1981_08
特許番号
US04284823

関連ノート

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