Sodium Hydroxide → N-(5-Amino-2-mercaptomethylpentanoyl)-L-tryptophane

HRID 894896ノート

反応式

HRID 894896 の反応式
FC(F)(F)C(O)=O.C[O:9][C:10](=[O:35])[C@H:11]([CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)[NH:12][C:13](=[O:24])[CH:14]([CH2:19][S:20]C(=O)C)[CH2:15][CH2:16][CH2:17][NH2:18].[OH-].[Na+].[H][H]>CO>[NH2:18][CH2:17][CH2:16][CH2:15][CH:14]([CH2:19][SH:20])[C:13]([NH:12][C@H:11]([C:10]([OH:35])=[O:9])[CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)=[O:24]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 86736009HCID 86736009、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 53870878N-(5-Amino-2-mercaptomethylpentanoyl)-L-tryptophane

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N-(2-acetylthiomethyl-5-aminopentanoyl)-L-tryptophane methyl ester trifluoroacetate (3 g) in methanol (60 ml) N sodium hydroxide (60 ml) is added. After four hours the solution is applied to a column of Dowex 50 ion exchange resin in the hydrogen cycle. After washing with water, the N-(5-amino-2-mercaptomethylpentanoyl)-L-tryptophane is eluted with pyridine-acetic acid buffer at pH 6.5.

後処理

  1. washAfter washing with water
  2. washthe N-(5-amino-2-mercaptomethylpentanoyl)-L-tryptophane is eluted with pyridine-acetic acid buffer at pH 6.5

出典と根拠

ORDレコード
ord-832c5e16baf44737b2c5d458a5e775f8
出典データセット
uspto-grants-1981_08
特許番号
US04284779

反応ノート

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