3-Methoxybenzaldehyde → 3-methoxy-beta-methylstyrene Oxide

HRID 894921

反応式

HRID 894921 の反応式
[C:1]1([SH+]C2C=CC=CC=2)C=CC=C[CH:2]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[CH:19]=[O:20]>O1CCCC1>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[CH:19]1[O:20][CH:1]1[CH3:2]

参加物

4

反応物 2

HCID 115693-MethoxybenzaldehydeHCID 22290449Diphenylsulfonium

生成物 1

HCID 204969033-methoxy-beta-methylstyrene Oxide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-78 °C

実験手順

To a -78° C. solution of diphenylsulfonium ethylide (1.0 mole) in tetrahydrofuran (one liter) is slowly added 3-methoxybenzaldehyde (1.0 mole). The reaction mixture is stirred at -78° C. for 3 hours and then allowed to warm to room temperature. It is then added to ether-water and the ether phase separated. The ether phase is washed with water, dried (MgSO4) and evaporated. Fractional distillation of the residue gives the title product.

後処理

  1. customTo a -78° C.
  2. temperatureto warm to room temperature
  3. customthe ether phase separated
  4. washThe ether phase is washed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. distillationFractional distillation of the residue

出典と根拠

ORDレコード
ord-eb68040193eb4bed94e392be00f7957a
出典データセット
uspto-grants-1981_08
特許番号
US04284829

関連ノート

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